Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC041
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-08-10 09:35
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 1/2+1/4+1/2+1/4 caps Madopar HBS a 125mg 2 uvece u 21h Older patient

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 12, 'TN': 11, 'TP': 30, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 8, 'TN': 9, 'TP': 34, 'FP': 21}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 23, 'TN': 15, 'TP': 19, 'FP': 15}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 13.34
timePerCircleCoV 0.106935
timePerCircleSlope -0.0261869
meanError 1.34174
tremorFreq 6.64062
tremorRelPower 31.5086
tremorGyroAmpMean 0.0301103
tremorGyroAmpSlope -0.00123734
tremorGyroAmpCoV 0.611731
tremorCoordAmpMean 0.0431652
tremorCoordAmpSlope -0.00268546
tremorCoordAmpCoV 0.494408
tremorAccAmpMean 0.0351929
tremorAccAmpSlope -0.0029739
tremorAccAmpCoV 0.570538
tremorPcRelVar 0.62338
tremorPcX 0.837686
tremorPcY 0.546152

Circle Segment 1

Duration 16.48 s, Accuracy Estimate 1.178 (lower is better)

Circle Segment 2

Duration 14.12 s, Accuracy Estimate 1.192 (lower is better)

Circle Segment 3

Duration 13.36 s, Accuracy Estimate 1.194 (lower is better)

Circle Segment 4

Duration 13.04 s, Accuracy Estimate 1.181 (lower is better)

Circle Segment 5

Duration 12.56 s, Accuracy Estimate 1.136 (lower is better)

Circle Segment 6

Duration 13.84 s, Accuracy Estimate 1.16 (lower is better)

Circle Segment 7

Duration 13.96 s, Accuracy Estimate 1.337 (lower is better)

Circle Segment 8

Duration 11.56 s, Accuracy Estimate 1.268 (lower is better)

Circle Segment 9

Duration 12.92 s, Accuracy Estimate 1.157 (lower is better)

Circle Segment 10

Duration 11.56 s, Accuracy Estimate 2.615 (lower is better)

Spiral

numSpirals 8
timePerSpiralMean 33.38
timePerSpiralCoV 0.0716993
timePerSpiralSlope -0.00950098
meanError 1.44739
tremorFreq 6.44531
tremorRelPower 25.1104
tremorGyroAmpMean 0.0253995
tremorGyroAmpSlope 0.000159263
tremorGyroAmpCoV 0.359771
tremorCoordAmpMean 0.0434607
tremorCoordAmpSlope 0.000692462
tremorCoordAmpCoV 0.307358
tremorAccAmpMean 0.0374655
tremorAccAmpSlope 0.00044662
tremorAccAmpCoV 0.274093
tremorPcRelVar 0.575256
tremorPcX -0.269308
tremorPcY -0.963054

Spiral Segment 1

Duration 37.76 s, Accuracy Estimate 1.287 (lower is better)

Spiral Segment 2

Duration 30.24 s, Accuracy Estimate 1.4 (lower is better)

Spiral Segment 3

Duration 34.04 s, Accuracy Estimate 1.268 (lower is better)

Spiral Segment 4

Duration 34.28 s, Accuracy Estimate 1.457 (lower is better)

Spiral Segment 5

Duration 30.92 s, Accuracy Estimate 1.442 (lower is better)

Spiral Segment 6

Duration 34.84 s, Accuracy Estimate 1.451 (lower is better)

Spiral Segment 7

Duration 32.44 s, Accuracy Estimate 1.783 (lower is better)

Spiral Segment 8

Duration 32.52 s, Accuracy Estimate 1.491 (lower is better)

Elel

eDurationMean 0.673143
eDurationStd 0.180253
eDurationStdnorm 0.267779
eDurationMedian 0.62
eDurationQuartdelta 0.1775
eDurationQuartdeltanorm 0.28629
eDurationKurt 4.67152
eDurationTrenddiff -0.085
eDurationTrendratio 0.875912
eWidthMean 5.60263
eWidthStd 1.2221
eWidthStdnorm 0.21813
eWidthMedian 5.499
eWidthQuartdelta 1.78425
eWidthQuartdeltanorm 0.324468
eWidthKurt 2.56642
eWidthTrenddiff 0.819
eWidthTrendratio 1.16279
eHeightMean 10.1222
eHeightStd 2.50766
eHeightStdnorm 0.24774
eHeightMedian 9.828
eHeightQuartdelta 2.25225
eHeightQuartdeltanorm 0.229167
eHeightKurt 10.6459
eHeightTrenddiff 1.053
eHeightTrendratio 1.11538
eAspectMean 0.567539
eAspectStd 0.122236
eAspectStdnorm 0.215378
eAspectMedian 0.564706
eAspectQuartdelta 0.1857
eAspectQuartdeltanorm 0.328844
eAspectKurt 3.07902
eAspectTrenddiff 0.0991403
eAspectTrendratio 1.19574
eSlantMean -0.232907
eSlantStd 0.199726
eSlantStdnorm -0.857537
eSlantMedian -0.291667
eSlantQuartdelta 0.212212
eSlantQuartdeltanorm -0.727585
eSlantKurt 5.79436
eSlantTrenddiff 0.0097032
eRtopMean 0.580785
eRtopStd 0.103846
eRtopStdnorm 0.178802
eRtopMedian 0.587302
eRtopQuartdelta 0.127811
eRtopQuartdeltanorm 0.217625
eRtopKurt 2.85916
eRtopTrenddiff 0.0901163
eRbotMean 1.02243
eRbotStd 0.32044
eRbotStdnorm 0.313411
eRbotMedian 1.02222
eRbotQuartdelta 0.334957
eRbotQuartdeltanorm 0.327676
eRbotKurt 4.28766
eRbotTrenddiff 0.0377358
eRrightMean 0.76966
eRrightStd 0.0651695
eRrightStdnorm 0.0846731
eRrightMedian 0.767123
eRrightQuartdelta 0.0867043
eRrightQuartdeltanorm 0.113025
eRrightKurt 3.82284
eRrightTrenddiff 0.0382353
eRleftMean 0.473351
eRleftStd 0.132299
eRleftStdnorm 0.279494
eRleftMedian 0.483871
eRleftQuartdelta 0.157494
eRleftQuartdeltanorm 0.325488
eRleftKurt 5.67249
eRleftTrenddiff -0.00927972
lDurationMean 0.812143
lDurationStd 0.235439
lDurationStdnorm 0.289898
lDurationMedian 0.74
lDurationQuartdelta 0.25625
lDurationQuartdeltanorm 0.346284
lDurationKurt 10.6383
lDurationTrenddiff -0.12
lDurationTrendratio 0.855422
lWidthMean 7.85237
lWidthStd 1.62015
lWidthStdnorm 0.206326
lWidthMedian 7.371
lWidthQuartdelta 1.638
lWidthQuartdeltanorm 0.222222
lWidthKurt 4.4816
lWidthTrenddiff 0.585
lWidthTrendratio 1.08333
lHeightMean 19.0142
lHeightStd 1.80596
lHeightStdnorm 0.0949798
lHeightMedian 19.071
lHeightQuartdelta 2.13525
lHeightQuartdeltanorm 0.111963
lHeightKurt 3.3475
lHeightTrenddiff -0.468
lHeightTrendratio 0.975758
lAspectMean 0.415975
lAspectStd 0.0898976
lAspectStdnorm 0.216113
lAspectMedian 0.384146
lAspectQuartdelta 0.130627
lAspectQuartdeltanorm 0.340046
lAspectKurt 2.71955
lAspectTrenddiff 0.0394145
lAspectTrendratio 1.10654
lSlantMean -0.118507
lSlantStd 0.11985
lSlantStdnorm -1.01134
lSlantMedian -0.115108
lSlantQuartdelta 0.156249
lSlantQuartdeltanorm -1.35741
lSlantKurt 2.68346
lSlantTrenddiff 0.0642575
lRtopMean 0.690124
lRtopStd 0.134456
lRtopStdnorm 0.194828
lRtopMedian 0.712644
lRtopQuartdelta 0.228289
lRtopQuartdeltanorm 0.320341
lRtopKurt 2.54259
lRtopTrenddiff 0.103009
lRbotMean 1.0153
lRbotStd 0.284062
lRbotStdnorm 0.279783
lRbotMedian 1.02857
lRbotQuartdelta 0.344458
lRbotQuartdeltanorm 0.33489
lRbotKurt 3.10786
lRbotTrenddiff -0.108824
lRrightMean 0.818955
lRrightStd 0.0697956
lRrightStdnorm 0.0852252
lRrightMedian 0.819209
lRrightQuartdelta 0.117463
lRrightQuartdeltanorm 0.143386
lRrightKurt 2.46955
lRrightTrenddiff -0.00525555
lRleftMean 0.393583
lRleftStd 0.117
lRleftStdnorm 0.297269
lRleftMedian 0.385135
lRleftQuartdelta 0.130291
lRleftQuartdeltanorm 0.338299
lRleftKurt 3.05731
lRleftTrenddiff -0.023467

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.965469
sumTouchScores 19.3094
meanMovementTime 1.00079
numTouches 20
undershootPercentage 0
overshootPercentage 5

FITTS Long Modified

meanTouchScore 0.933333
sumTouchScores 14
meanMovementTime 1.26143
numTouches 15
undershootPercentage 6.66667
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 25.28
timePerZigzagCoV 0.124614
timePerZigzagSlope -0.0738924
meanError 2.3976
tremorFreq 6.93359
tremorRelPower 30.9289
tremorGyroAmpMean 0.0672239
tremorGyroAmpSlope 0.00789832
tremorGyroAmpCoV 0.434329
tremorCoordAmpMean 0.0715402
tremorCoordAmpSlope 0.00236367
tremorCoordAmpCoV 0.433771
tremorAccAmpMean 0.0552063
tremorAccAmpSlope 0.00381505
tremorAccAmpCoV 0.434496
tremorPcRelVar 0.797467
tremorPcX 0.105541
tremorPcY 0.994415

ZigZag Segment 1

Duration 29.44 s, Accuracy Estimate 2.037 (lower is better)

ZigZag Segment 2

Duration 27.4 s, Accuracy Estimate 2.12 (lower is better)

ZigZag Segment 3

Duration 23.48 s, Accuracy Estimate 2.203 (lower is better)

ZigZag Segment 4

Duration 24.56 s, Accuracy Estimate 2.561 (lower is better)

ZigZag Segment 5

Duration 21.52 s, Accuracy Estimate 3.066 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 22.056
timePerZigzagCoV 0.169511
timePerZigzagSlope -0.0943054
zigzagHeightMean 67.9037
zigzagHeightCoV 0.0589244
zigzagHeightSlope 0.0240735
meanError 0.0380653
tremorFreq 6.64062
tremorRelPower 20.1683
tremorGyroAmpMean 0.0710473
tremorGyroAmpSlope 0.00100359
tremorGyroAmpCoV 0.459519
tremorCoordAmpMean 0.0789054
tremorCoordAmpSlope 0.00440334
tremorCoordAmpCoV 0.746768
tremorAccAmpMean 0.0561597
tremorAccAmpSlope 0.00238518
tremorAccAmpCoV 0.462033
tremorPcRelVar 0.878874
tremorPcX -0.0567928
tremorPcY 0.998386

ZigZag Offset Segment 1

Duration 27.68 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 2

Duration 21.32 s, Accuracy Estimate 0.029 (lower is better)

ZigZag Offset Segment 3

Duration 22.68 s, Accuracy Estimate 0.026 (lower is better)

ZigZag Offset Segment 4

Duration 21.32 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 5

Duration 17.28 s, Accuracy Estimate 0.054 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8852889171152403}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.45015119671496273}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.464004602582781}